1. Waterston is the daughter of Lynn Louisa , a former model, and Sam Waterston, an Oscar-nominated actor. She is a sister of actress Elisabeth Waterston and director Graham Waterston.
2. She also has a half-brother, James Waterston, who is also an actor.
3. In 2007, Waterston performed in the play Los Angeles by Julian Sheppard and in 2008, she performed in the play Kindness by Adam Rapp. In 2010, Waterston played the role of Gena in the original Off-Broadway production of Bachelorette, played in the 2011 film version by Lizzy Caplan.
4. In 2011, she played Anya in the Classic Stage Company revival of The Cherry Orchard.
5. Also in 2011, she performed in Dreams of Flying, Dreams of Falling, also by Adam Rapp at the Classic Stage Company.